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α-促黑激素 (α-MSH)是一种前阿片促皮质激素原衍生肽。此文介绍了α-MSH的来源、分布、生理功能及其受体的种类和分布。α-MSH对各种急性炎症和慢性炎症均有抗炎作用。α-MSH能够以内分泌、自分泌和旁分泌形式直接作用于外周组织炎性细胞上 ,发挥抗炎症作用。 α-MSH主要作用于单核巨噬细胞和嗜中性粒细胞 ,抑制其促炎性细胞因子如 TNF-α的分泌 ,促进其抗炎性细胞因子如 IL-1 0的分泌 ,抑制其 NO的生成及其向炎症部位游走等。中枢神经系统产生的 α-MSH可以通过激活外周 β2 -肾上腺素能交感神经发挥抗外周组织炎症作用。
Alpha-melanocyte stimulating hormone (alpha-MSH) is a pre-opioid corticotropin-derived peptide. This article describes the origin, distribution, physiological function of α-MSH and its receptor types and distribution. Alpha-MSH has anti-inflammatory effects on a variety of acute and chronic inflammation. α-MSH can endocrine, autocrine and paracrine forms of direct action on peripheral tissue inflammatory cells, play an anti-inflammatory effect. α-MSH mainly acts on monocytes and neutrophils, inhibits the secretion of proinflammatory cytokines such as TNF-α, promotes the secretion of anti-inflammatory cytokines such as IL-10, and inhibits the production of NO The formation and its migration to the site of inflammation and so on. Α-MSH produced by the central nervous system exerts anti-peripheral tissue inflammation by activating peripheral β2-adrenergic sympathetic nerve.