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间碘代苄胍MIBG作为肾上腺髓质显像剂,临床诊断嗜络细胞瘤等疾病,已经引起人们注意,目前也有人用高比度的M~(123)IBG来进行人的心肌显像,试图获得一种新的心肌显像刘。 对于像MIBG这类含碘的化合物,由于分子苯环上不含给电子的活化基团,又没有找到合适的高沸点的有机溶剂作为介质,在水溶液中由于温度较低和溶剂化作用,同位素交换反应速度很低。J.Mangner等人发展了一种用(NH_4)_2SO_4作为反应介质的方法,取得较好效果。
Iodobenzoguanidine MIBG as adrenal medulla imaging agents, clinical diagnosis of glioma and other diseases, has drawn people’s attention, there are also some people with high than the M ~ (123) IBG for human myocardial imaging, Trying to get a new kind of myocardial imaging Liu. For iodine-containing compounds such as MIBG, due to the absence of electron-donating activating groups on the benzene ring of the molecule and the absence of a suitable high-boiling organic solvent as a medium, the isotopes Exchange reaction rate is very low. J.Mangner, who developed a (NH_4) _2SO_4 as a reaction medium, and achieved good results.