论文部分内容阅读
目的:探讨伏立康唑引起精神症状的表现及转归,为合理安全用药提供参考。方法:对1996年6月至2016年6月国内使用伏立康唑引起精神症状的129例病例进行回顾性及描述性分析。结果:在129例伏立康唑引起的精神症状不良反应的病例中,其中56例性别已知,男性病例多于女性,无年龄显著差异。其发生时间多在用药2~3d之后,停药或者用药干预后大部分能完全缓解。结论:患者用药过程中,临床药师要做好用药监护,做好疾病治疗前精神疾患危险性评估,加强医师、护士对精神症状不良反应的认识,加强患者的用教育,预防不良反应发生。
Objective: To investigate the manifestation and outcome of voriconazole-induced psychiatric symptoms and provide a reference for rational and safe medication. Methods: A retrospective and descriptive analysis of 129 cases of voriconazole-induced psychiatric symptoms in China from June 1996 to June 2016 was conducted. Results: Of the 129 cases of voriconazole-induced adverse psychiatric symptoms, 56 were sexually known, and there were more males than females, with no significant difference in age. The occurrence of more than 2 to 3 days after treatment, most of the withdrawal or drug treatment can be completely relieved. Conclusion: During the course of medication, clinical pharmacists should take care of medication, evaluate the risk of mental illness before treatment, strengthen the understanding of adverse reactions of psychiatric symptoms by physicians and nurses, and strengthen the education of patients and prevent the occurrence of adverse reactions.