Objective: Based on the health belief model, the depression status of medical students was analyzed in order to provide new ideas for the intervention of mental health problems of medical students. Methods: By using the method of stratified cluster sampling, 1053 medical students in a medical college in Hainan province were investigated with self-designed general situation questionnaire, SCL-90, CSQ and emotional management health belief questionnaire. Results: The positive rate of depressive symptoms in medical students was 17.5％. Multivariate unconditional Logistic regression analysis showed that gender, coping style, perceived obstacles, perceived severity, perceived susceptibility and self-efficacy were related factors of depression in medical studengts. Conclusion: The related factors of depression in medical students include personal factors and the health belief factors such as perceived obstacles, perceived severity, perceived susceptibility and self-efficacy. Psychological intervention based on Health belief model can be used for intervention of medical students .