论文部分内容阅读
抗原特异性IgG亚类抗体缺陷是引起多种疾病,尤其是儿童反复呼吸道感染的重要原因之一。已证实细菌多糖特异性IgG_2抗体缺陷,易发生肺炎球菌、流感杆菌等感染;而细菌外毒素及类毒素、病毒外壳蛋白等蛋白质抗原特异性IgG_1和/或IgG_3抗体缺陷,易发生相应细菌或病毒感染。抗原特异性IgG亚类抗体的检测,有助于某些临床疾病的诊断和治疗。本文试就抗原特异性IgG亚类抗体缺陷的产生机理、诊断及治疗等进行探讨。
Antigen-specific IgG subclass antibody deficiency is caused by a variety of diseases, especially one of the major causes of recurrent respiratory tract infections in children. Bacterial polysaccharides specific IgG2 antibody defects have been confirmed, prone to pneumococcus, influenza bacilli and other infections; and bacterial exotoxin and toxoid, viral coat protein and other protein antigen-specific IgG_1 and / or IgG_3 antibody defects prone to the corresponding bacteria or viruses infection. Detection of antigen-specific IgG subclass antibodies can help in the diagnosis and treatment of certain clinical conditions. This article attempts to study the mechanism of antigen-specific IgG subclass antibody defects, diagnosis and treatment.