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目的 观察人参茎叶皂苷和胆碱合用对Alzheimer病(AD)学习记忆的影响。方法 喹啉酸损毁老年大鼠双侧迈尼特基底核制备AD动物模型 ,一次性训练被动回避跳台实验和水迷宫空间分辨能力测试手段观察学习记忆变化。结果 人参茎叶皂苷 (4 0 0mg·kg-1·d-1)和胆碱 (2 0 0mg·kg-1·d-1)合用 ,AD大鼠在跳台中出现的错误反应次数 (ig13d)和学会迷宫所需的训练次数 (ig 16d)显著减少 ,且均比单用效应明显 ,合用后Q >1,其作用与 1,2 ,3,4 四氢吖啶(THA ,10mg·kg-1·d-1,ig)无明显差异。结论 人参茎叶皂苷和胆碱合用有协同改善AD学习记忆障碍的作用。
Objective To observe the effect of combined use of ginsenosides and choline on the learning and memory of Alzheimer disease (AD). METHODS: The animal model of AD was established by quinolinic acid in the bilateral Meinit’s basal nucleus in aged rats. One-time training with passive avoidance platform test and water maze spatial resolution test were used to observe changes in learning and memory. Results Ginseng stem and leaf saponins (400 mg·kg-1·d-1) and choline (200 mg·kg-1·d-1) were used together. The number of false reactions in AD rats that occurred in the platform (ig13d) The number of trainings (ig 16d) required to learn mazes was significantly reduced, and all had significant effects compared to single use. After combined use, Q > 1, and its effect was 1,2,3,4 tetrahydroacridine (THA, 10 mg·kg- 1 d-1, ig) No significant difference. Conclusion The combination of ginseng stem saponin and choline can synergistically improve the learning and memory impairment of AD.