论文部分内容阅读
业已证明,某些严重再生障碍性贫血(SAA)病人外周血和骨髓的T淋巴细胞在体外能抑制造血,在T细胞中,带IgG受体者(Tγ-细胞)具有这种抑制作用。并且,单纯性红细胞再生障碍性贫血(PR-CA)可能T淋巴细胞亚群不平衡而以抑制性T细胞占优势。基于这些发现,再障(AA)的处理可试用非选择性的免疫抑制药物和/或抗淋巴细胞球蛋白作免疫治疗。本文报告某些T-依赖性免疫调节异常的AA病例,并认为这些病例可能为免疫调节药物所纠正。笔者研究了6例原发性再生障碍性疾病(3例PR-CA,3例SAA)外周血的T淋巴细胞亚群,根据Moretta等的报告,以IgG(Tγ)或IgM(Tμ)受体加以鉴别。所有病例均曾接受过类固醇、维生素B(?)、雄
It has been demonstrated that peripheral blood and bone marrow T lymphocytes in some patients with severe aplastic anemia (SAA) inhibit hematopoiesis in vitro and that this effect is mediated by T gamma receptors in T cells. Moreover, simple erythroid aplastic anemia (PR-CA) may be unbalanced T lymphocyte subsets and predominantly suppressor T cells. Based on these findings, treatment of aplastic anemia (AA) can be used for immunotherapy with nonselective immunosuppressive drugs and / or anti-lymphocyte globulin. This article reports some cases of AA with abnormal T-dependent immunomodulation and suggests that these cases may be corrected for immunomodulatory drugs. The authors studied T lymphocyte subsets in peripheral blood from 6 patients with primary aplastic disease (3 PR-CA and 3 SAA). According to reports by Moretta et al., IgG (Tγ) or IgM (Tμ) receptors Be identified. All cases had received steroids, vitamin B (?), Male