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目的:探讨15-羟基前列腺素脱氢酶(15-PGDH)在胃癌组织和癌旁正常组织中的表达及其与临床病理特征的关系,初步评价15-PGDH在胃癌发生、发展中的作用及其意义。方法:随机收集60例胃癌手术病人的癌组织及相应癌旁正常组织,应用免疫组织化学检测15-PGDH表达特征并进行评分,进一步分析15-PGDH的表达与胃癌临床病理参数的关系。结果:胃癌组织中15-PGDH的表达水平显著降低甚至缺失(p<0.01)。结合胃癌的临床病理学特征统计分析表明,15-PGDH在低分化胃癌中明显低于高分化胃癌中的表达(p<0.05);15-PGDH在TNMⅢ期和Ⅳ期患者的胃癌组织中的染色明显低于在Ⅰ期和Ⅱ期组织中的表达(p<0.05);存在淋巴结转移的胃癌组织中15-PGDH表达显著低于无淋巴结转移胃癌组织中的表达(p<0.01)。结论:胃癌中15-PGDH的表达减少或缺失可能是胃癌发生、发展及浸润转移的重要机制之一,15-PGDH在胃癌中可能扮演着抑癌基因的角色。
Objective: To investigate the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in gastric cancer tissues and adjacent normal tissues and its relationship with clinicopathological features, and to evaluate the role of 15-PGDH in the development and progression of gastric cancer. Its significance. Methods: 60 cases of gastric cancer patients were randomly collected from the cancer tissue and adjacent normal tissues. The expression of 15-PGDH was detected by immunohistochemistry and scored. The relationship between 15-PGDH expression and clinicopathological parameters of gastric cancer was further analyzed. RESULTS: The expression level of 15-PGDH in gastric cancer tissues was significantly decreased or even lost (p<0.01). Combined with the clinical and pathological features of gastric cancer, statistical analysis showed that 15-PGDH was significantly lower in poorly differentiated gastric cancer than in well-differentiated gastric cancer (p<0.05); the staining of 15-PGDH in gastric cancer tissues of patients with stage III and IV TNM It was significantly lower than that in the stage I and II tissues (p<0.05); the expression of 15-PGDH was significantly lower in gastric cancer tissues with lymph node metastasis than in those without lymph node metastasis (p<0.01). CONCLUSION: The decrease or absence of 15-PGDH expression in gastric cancer may be one of the important mechanisms of the occurrence, development, invasion and metastasis of gastric cancer. 15-PGDH may play a role of tumor suppressor gene in gastric cancer.