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目的探讨环磷酸胺（CTX）冲击治疗与常规口服治疗对狼疮性肾炎（LN）的治疗效果。方法对LN患者146例按年龄、性别、病程、尿蛋白定量／24h、肾功能、免疫学改变随机分两组：冲击治疗组76例，常规口服组70例，并进行随访。对其临床疗效、肾功能变化、免疫学变化进行统计处理。结果CTX冲击治疗的疗效优于常规口服治疗（x2=7．14，p＜0．05）；肾功能生化指标明显改善（t=1．86，p＜0．05）；抗核抗体转阴率高（x2=20．13，p＜0．01）；C3恢复正常率高（x2=5．98，p＜0．05）。结论CTX冲击治疗优于常规口服治疗。
Objective To investigate the therapeutic effect of cyclophosphamide (CTX) and conventional oral therapy on lupus nephritis (LN). Methods One hundred and sixty-six patients with LN were randomly divided into two groups randomly according to age, sex, duration of disease, urinary protein quantitation / 24h, renal function and immunological changes: 76 in shock group and 70 in conventional oral group. The clinical efficacy, renal function changes, immunological changes were statistically analyzed. Results The therapeutic effect of CTX was superior to that of conventional oral therapy (x2 = 7.14, p <0.05); the renal biochemical parameters were significantly improved (t = 1.86, p <0.05) (X2 = 20.13, p <0.01). The rate of C3 recovery was high (x2 = 5.98, p <0.05). Conclusion CTX impact treatment is superior to conventional oral treatment.