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目的:探讨戊聚硫钠(PPS)对慢性非细菌性前列腺炎(CNP)大鼠的治疗作用。方法:选取6月龄健康成年雄性SD大鼠80只,体重315~450 g,去势后用苯甲酸雌二醇0.25 mg/(kg.d)皮下注射,每日1次,连续注射30 d建模。成功建立CNP大鼠动物模型后,随机等分为安慰剂组和PPS治疗组,每组40只,分别用PPS、生理盐水灌胃治疗,连续8周后,处死动物,前列腺组织,HE染色,观察其病理变化。结果:建模后各组大鼠前列腺出现不同程度的慢性炎症改变和炎症细胞的浸润。PPS治疗组大鼠前列腺炎症较治疗前明显好转,而安慰剂组炎症未见好转。结论:PPS对大鼠CNP有一定治疗作用,其作用机制可能与PPS可修复大鼠前列腺受损的GAG层,抑制炎症的发生相关。
Objective: To investigate the therapeutic effect of Pentosan Sodium Sulfate (PPS) on chronic nonbacterial prostatitis (CNP) rats. Methods: Eighty healthy 6-month-old male SD rats weighing 315-450 g were injected subcutaneously with estradiol benzoate 0.25 mg / (kg.d) once a day for 30 days Modeling. After successful establishment of animal models of CNP rats, rats were randomly divided into placebo group and PPS treatment group, 40 rats in each group, treated with PPS and saline respectively. After 8 weeks of continuous operation, animals, prostatic tissue and HE staining were performed, Observe the pathological changes. Results: After modeling, different degrees of chronic inflammation and infiltration of inflammatory cells appeared in the prostate of rats in each group. Prostate inflammation in rats treated with PPS was significantly improved compared with that before treatment, while inflammation in placebo group showed no improvement. Conclusion: PPS has a certain therapeutic effect on rat CNP, and its mechanism may be related to PAG repairing the damaged GAG layer of the prostate and inhibiting the inflammation.