目的研究胆汁反流性胃炎（ＢＲＧ）患者胆囊（ＧＢ）排空功能及其与胆汁反流的关系．方法采用随机、双盲和对照的方法，应用实时超声检查研究了３２例ＢＲＧ患者和２６例健康对照者的空腹ＧＢ容量（ＦＧＶ）和餐后ＧＢ排空功能．结果ＦＧＶ（ｃｍ３，ｘ±ｓｘ）ＢＲＧ患者（２３５±１５）明显大于对照组（１９７±１３，Ｐ＜００１）．餐后１５ｍｉｎＧＢ排出量（ＧＥＦ）ＢＲＧ患者即显著减少（Ｐ＜００１），餐后４５ｍｉｎ减少达最大（４５３％ｖｓ７０３％）．最大ＧＥＦＢＲＧ患者（６５４％）明显少于对照组（８０２％，Ｐ＜００１）．ＧＢ排空速度ＢＲＧ患者显著慢于对照组（Ｐ＜００１）．结论ＢＲＧ患者ＧＢ排空明显不良，可能系ＧＢ收缩无力和（或）Ｏｄｄｉ括约肌松弛不良所致；餐后ＧＥＦ减少与ＦＧＶ增多有关，从而使消化间期排入肠道的胆汁增多，当同时存在胃肠运动功能紊乱时即可反流入胃 Objective To investigate the role of gallbladder (GB) emptying in patients with bile reflux gastritis (BRG) and its relationship with bile reflux. Methods The fasting GBV (FGV) and postprandial GB (GB) emptying function of 32 patients with BRG and 26 healthy controls were studied by real-time sonography in a randomized, double-blind and controlled manner. Results The patients with FGV (cm3, x ± sx) BRG (235 ± 15) were significantly larger than those in the control group (197 ± 13, P <001). The amount of GBE (GEF) significantly decreased at 15 min after meal (P <001), and reached the maximum at 45 min after meal (453% vs 703%). The largest GEFBRG patients (65  4%) was significantly less than the control group (80  2%, P <0  01). The GBG emptying rate was significantly lower in patients with BRG than in the control group (P <001). CONCLUSIONS: GB was evidently bad in BRG patients, which may be caused by GB weakening and / or Oddi sphincter relaxation. The decrease of postprandial GEF is related to the increase of FGV, which leads to the increase of intestinal bile during the interim period. Gastrointestinal motility disorders can flow back into the stomach