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目的评价细胞DNA定量检测技术在宫颈癌筛查中的应用价值及其临床意义。方法对受检的967例女性采用宫颈刷取材进行液基细胞学制片,分别行巴氏染色和DNA染色,对DNA染色片进行全自动DNA倍体扫描诊断。结果 967例女性中DNA倍体阳性112例,阳性检出率为11.58%。对DNA倍体检测异常的部分病例进一步行阴道镜检查及宫颈活检。结论宫颈癌瘤的发展与宫颈细胞DNA倍体异常密切相关,随着宫颈病变程度的增加,宫颈二倍体细胞逐渐减少,而宫颈多倍体细胞逐步增加。在宫颈癌筛查中检测宫颈上皮细胞中DNA倍体变化情况对女性宫颈癌瘤高危人群的筛查具有重要的价值。
Objective To evaluate the value of quantitative detection of DNA in cervical cancer screening and its clinical significance. Methods Nine hundred and seventy-six women with cervical spondylosis were treated with liquid-based cytology, Papa stain and DNA stain respectively. Results Among the 967 women, 112 DNA positive were found, the positive rate was 11.58%. In some cases of DNA ploidy abnormalities further colposcopy and cervical biopsy. Conclusion The development of cervical cancer is closely related to DNA ploidy in cervical cells. With the increase of cervical lesions, the number of cervical diploid cells gradually decreases and the number of cervical polyploid cells gradually increases. Detection of cervical epithelial cells in cervical cancer screening changes in DNA ploidy screening of women with high risk of cervical cancer has important value.