综述了近年来光学活性 α-氨基膦酸及其酯的各种不对称合成方法 ,包括化学计量不对称合成和催化不对称合成。重点介绍了近年发展起来的催化不对称合成方法 ,并且对各种合成方法的优劣进行了评述。 In recent years, various asymmetric synthesis methods of optically active α-aminophosphonic acid and its esters, including stoichiometric asymmetric synthesis and catalytic asymmetric synthesis, were reviewed. The catalytic asymmetric synthesis methods developed in recent years are mainly introduced, and the advantages and disadvantages of various synthetic methods are reviewed.