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应用抗人增殖细胞抗体Ki-67,以ABC法对15例恶性黑素瘤(MM)、17例后天性痣、18例先天性小痣及3例先天性巨痣进行标记染色。结果显示:13例MM阳性(细胞阳性率2％～33％),3型色素痣全部阴性。培养的MM细胞阳性率88％。结果提示:就黑素细胞肿瘤而言,Ki-67是鉴别良、恶性的一个较敏感和特异的指标;目前用Ki-67这种直接反应肿瘤增生活性的方法尚不足以反映不同型良性黑素细胞肿瘤之间存在的微小差别。
Using anti-human proliferating cell antibody Ki-67, 15 cases of malignant melanoma (MM), 17 cases of acquired delirium, 18 cases of congenital spasms and 3 cases of congenital giant salamanders were stained by ABC method. The results showed that: 13 cases of MM positive (cell positive rate of 2% to 33%), all negative for type 3 pigmented nevus. The positive rate of cultured MM cells was 88%. The results suggest that Ki-67 is a more sensitive and specific marker for the differentiation of benign and malignant melanocyte tumors. The current method of using Ki-67 to directly reflect the tumor proliferation activity is not enough to reflect different types of benign black. There are minor differences between prime cell tumors.