早年,曾试图经会阴或骶部径路作局部切除以治愈直肠癌。1908年Miles氏描写了一种包括肿瘤的全部淋巴扩散区域在内的直肠癌根治手术。据死于直肠癌的患者的病理学研究,使他认识到需要一个腹部径路以控制肿瘤通过伴随上痔血管的淋巴流的向上扩散。晚期病人伴有近端淋巴管的堵塞,致使肿瘤逆流至中和下痔淋巴管。他因而主张对每个直肠癌患者行提 In early years, he had tried to remove localized resections through the perineum or palate to cure colorectal cancer. In 1908, Miles described a radical resection of the rectal cancer that included the entire lymphatic spread of the tumor. According to the pathological study of patients who died of rectal cancer, he realized that he needed an abdominal approach to control the upward diffusion of tumors through the lymph flow accompanying the epigastric vessels. The late patients are accompanied by a blockage of the proximal lymphatic vessels, which causes the tumor to flow back to the medial and inferior iliac lymphatic vessels. He therefore advocates that every patient with rectal cancer should be mentioned