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集落刺激因子(CSFs)是一组体内外促进造血祖细胞增殖、分化为各种成熟细胞的低分子量糖蛋白质。五种CSFs 已经分子克隆,并由基因工程生产重组人CSFs。CSFs的研究表明,CSFs 不仅参于造血的调节,而且参于血液病细胞生长及机体免疫功能的调节。CSFs 的作用机理及临床应用已取得明显进展。实验证明:CSFs 对细胞的作用并非通过细胞内cAMP 水平而达到,可能是通过CSFs 受体而改变细胞内基质磷酸化、Ca~(2+)浓度和pH 而产生效果。
Colony stimulating factors (CSFs) are a group of low molecular weight glycoproteins that promote the proliferation of hematopoietic progenitor cells and differentiate into various mature cells in vitro and in vivo. Five CSFs have been molecularly cloned and genetically engineered to produce recombinant human CSFs. Studies of CSFs have shown that CSFs are involved not only in the regulation of hematopoiesis but also in the regulation of hematopoietic cell growth and immune function. The mechanism of action and clinical application of CSFs have made significant progress. Experiments have shown that the effect of CSFs on cells is not achieved by intracellular cAMP levels, but may be effected by changing the intracellular matrix phosphorylation, Ca 2+ concentration, and pH through CSFs receptors.