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本文用Tn抗原的单克隆抗体,ABC免疫酶标组化法观察了62例胃食管癌,47例慢性胃炎和27例大致正常胃粘膜Tn抗原的表达,其中胃食管癌Tn抗原表达阳性率达79.0%,显著高于慢性胃炎和大致正常胃粘膜组。本文就Tn抗原重新暴露表达在胃食管粘膜细胞癌变和临床应用中的意义进行了讨论。
In this study, the expression of Tn antigen in 62 cases of gastroesophageal carcinoma, 47 cases of chronic gastritis and 27 cases of normal gastric mucosa was observed by Tn antigen monoclonal antibody and ABC immunohistochemical method. The positive rate of Tn antigen expression in gastroesophageal carcinoma was observed. 79.0% was significantly higher than chronic gastritis and roughly normal gastric mucosa groups. This article discusses the significance of reexposed Tn antigen expression in gastroesophageal mucosal cell carcinoma and clinical applications.