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Suppression of Akt/mTOR pathway Enhances (-)-Gossypol-induced Cytotoxicity in Androgen-Independent P
[会议论文] 作者：Jiqin lian,Zhenhong Ni,Bin Wang,Fengtian He,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
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Suppression of Akt/mTOR pathway Enhances (-)-Gossypol-induced Cytotoxicity in Androgen-Independent P
[会议论文] 作者：Jiqin lian,Zhenhong Ni,Bin Wang,Fengtian He,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
The natural BH3-mimetic (-)-gossypol is currently undergoing Phase Ⅱ-Ⅲ clinical trials forhuman prostate cancer and showing promising efficacy.Here we show that suppression of Akt/mTOR pathway by NVP-...
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol bysuppressing ERK-mediated protective
[会议论文] 作者：Bin Wang,Zhenhong Ni,Xinzhe Li,Jiqin Lian,Fengtian He,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
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Targeting the MIR34C-5pATG4Bautophagy axis enhances the sensitivity of cervical cancer cells to pira
[会议论文] 作者：Yaran Wu,Zhenhong Ni,Xiaojing Yan,Fengtian He,Jiqin Lian,
来源：第十一届西南三省一市生物化学与分子生物学学术研讨会 年份：2016
Pirarubicin (THP) is a newer generation anthracycline anticancer drug.In the clinic, THP and THP-based combination therapies have been demonstrated to be ef...
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol bysuppressing ERK-mediated protective
[会议论文] 作者：Bin Wang,Zhenhong Ni,Xinzhe Li,Jiqin Lian,Fengtian He,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
Natural BH3-memitic (-)-gossypol ((-)-Gos) shows promising antitumor efficacy in severalkinds of cancers, but it induces protective autophagy in hepatocellular carcinoma (HCC)cells, which leads to dru...
Activation of AKT-AP1-FOXM1 signaling pathway confers sorafenib resistance to hepatocellular carcino
[会议论文] 作者：Xiaojing Yan,Lingxi Chen,Liangbo Sun,Tao Li,Fengtian He,Jiqin Lian,
来源：中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 年份：2018
Sorafenib is the first-line drug for advanced hepatocellular carcinoma(HCC),but the clinical response to sorafenib is seriously limited by drug resistance.In this study,we investigated the molecular m...
[会议论文] 作者：Zhenhong Ni,Bin Wang,Wen Ding,Ting Yang,Xinzhe Li,Jiqin Lian,Fengtian He,
来源：第八届全国医学生物化学与分子生物学、第五届全国临床应用生物化学与分子生物学、2013华东六省一市生物化学与分子生物学联合 年份：2013
Overexpression of anti-apoptotic protein Bcl-2 is involved in therapy-resistance in hepatocellular carcinoma (HCC).The BH3-mimetic ABT-737, a Bcl-2 inhibito...
Dichloroacetate enhances the anti-tumor effect of Pirarubicin via ROS-JNK pathway in liver cancer ce
[会议论文] 作者：Xiaojing Yan,Peng Xie,Lingxi Chen,Liangbo Sun,Tao Li,YueTing Zhang,Hanxi Xiao,Fengtian He,Jiqin Lian,
来源：中国生物化学与分子生物学会2019年全国学术会议 年份：2019
Liver cancer is one of the most common malignancies with high recurrence rate.Besides radiotherapy and surgery,chemotherapy also plays an important role in the treatment of liver cancer....
[会议论文] 作者：Zhenhong Ni,Jintao He,Yaran Wu,Xufang Dai,Xiaojing Yan,Bo Li,Xinzhe Li,Haojun Xiong,Jiqin Lian,Fengtian,
来源：中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 年份：2018
Phosphorylation is a major type of post-translational modification,which can influence the cellular physiological function.Atg4B,a key autophagy-related protein,has a potential effect on the survival...
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