Infectious diseases caused by microbes are a serious public safety issues associated with significant mortality and health-care costs in world-wide.Hence,the development of alternative novel drugs is
Quinolones are one of the most widely prescribed antimicrobial agents as they are generally well tolerated with excellent safety profile,favorable pharmacokinetic characteristics and broad antibacteri
A novel series of quinolone triazoles as antimicrobial agents were designed and synthesized,and their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spectra.
Triazole drugs including Fluconazole,Itraconazole and Voriconazole have been prevalently used in the antiinfective therapy and also exhibit good anti-MRSA potency.
5-Fluorouracil(5-FU)is a well-known antitumour agent widely used for the treatment of solid tumors.However,its clinical use is limited by many disadvantages such as short half-life,low selectivity,and
A series of novel sulfanilamide nitroimidazoles were synthesized via unique C-N cleavage of cyclic sulfanilamides by azole ring.Their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spe