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  5. Hydrogen sulfide releasing aspirin, ACS14, attenuates methylglyoxal and high glucose-induced oxidati

Hydrogen sulfide releasing aspirin, ACS14, attenuates methylglyoxal and high glucose-induced oxidati

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：lanbing510
【摘 要】
：
Aim: ACS14 is a novel aspirin analogue which releases hydrogen sulfide (H2S).Methylglyoxal (MG) is a reactive byproduct of glucose metabolism.High MG levels and oxidative stress are associated with di
【作 者】
：
Qian HUANG Piero Del SOLDATO Ling-yun WU Kaushik DESAI 
【机 构】
：
Department of Pharmacology, College of Medicine, The University of Saskatchewan, Saskatoon, SK,Canad
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
aspirin hydrogen sulfide methylglyoxal glucose oxidative stress 
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Aim: ACS14 is a novel aspirin analogue which releases hydrogen sulfide (H2S).Methylglyoxal (MG) is a reactive byproduct of glucose metabolism.High MG levels and oxidative stress are associated with diabetes and some other diseases.Our aim of this study is to investigate the effect of ACS14 on cellular MG levels and reactive oxygen species (ROS) production in cultured vascular smooth muscle (A10) cells in a comparison with aspirin and a H2S donor, NaHS.
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