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  5. Effects of CYP3A4*1G, CYP3AP1*3 and gender on pharmacokinetics of simvastatin and simvastatin acid i

Effects of CYP3A4*1G, CYP3AP1*3 and gender on pharmacokinetics of simvastatin and simvastatin acid i

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：baoxiuli
【摘 要】
：
Aim: To study effects of CYP3A4*1G (G＞A), CYP3AP1*3 (G＞A) and gender on pharmacokinetics of simvastatin and simvastatin acid.Methods: The polymorphisms of CYP3A4*1G and CYP3AP1*3 were determined by po
【作 者】
：
Wei-hong YANG Hong-ping XU Deng-zhi ZHAO Xiao-fei WANG Sheng-jun ZHANG Li-rong ZHANG 
【机 构】
：
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
CYP3A4*1G simvastatin simvastatin acid pharmacokinetics CYP3AP1*3 
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Aim: To study effects of CYP3A4*1G (G＞A), CYP3AP1*3 (G＞A) and gender on pharmacokinetics of simvastatin and simvastatin acid.Methods: The polymorphisms of CYP3A4*1G and CYP3AP1*3 were determined by polymerase chain reaction-restriction fragment length polymorphism.Serial blood samples were obtained up to 24 h after a single dose of 40 mg simvastatin intake in healthy Chinese volunteers.
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