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Objective To detect serum thrombopoietin (TPO) level of Hepatitis B cirrhosis patients and to study the relationship between serum TPO level and HBV viral load, Child-Pugh grade and platelets count in the hepatitis B patients with liver cirrhosis.Methods 26 cirrhosis patients and 7 healthy volunteers were included in the study.Liver cirrhosis diagnosis consistent with the clinical diagnosis, while excluding patients with alcoholic fatty liver disease, non-alcoholic liver patients autoimmune liver disease, and patients with liver cirrhosis caused by genetic metabolic and other reasons.