论文部分内容阅读
A hemodynamic model (HD) of dynamic contrast-enhancement magnetic resonance imaging (DCE-MRI) for breast cancer without blood sampling using a fixed T 1 value and based on the selection of reference muscle region was developed, which is an useful quantificational analysis tool for determining benign, malignant, as well as for deterring the therapeutical effect of chemotherapy for breast cancer.In HD of DCE-MRI, the volume transfer constant, Ktrans,and the extravascular volume fraction, Ve, were defined as two physiological parameters to distinguish the difference between cancer and normal tissue in Breast.HD of DCE-MRI has been further tested for normal clinical breast DCEMRI imaging data, which showed that the generated parametric maps clearly showed the tumors inner structure correlated with the distribution of KRtrans and Ve, R.Our investigation showed that HD of DCE-MRI may change routine MRI scan protocol for breast scanning and helpful for clinical application.With the more accurate data, the preliminary clinical results found significance in change of Ktrans before and after neoadjvant chemotherapy (P=0.003)between major histological response (MHR) group and non major histological response (NMHR) group.No difference in change of Ve and volume was found between MHR and NMHR groups.