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Objective: Obstructive sleep apnea(OSA) and metabolic syndrome(MetS) are common in clinical practice and both of them are independent risk factors for cardiovascular diseases(CVD).Growing experimental evidence connects chronic intermittent hypoxia of OSA to MetS, but the results were inconclusive due to various limitations.Our objective was to meta-analytically synthesize the existing evidence for the association of OSA with the risk of MetS prevalence.Methods: We searched multiple electronic databases for studies that evaluated the association of OSA and MetS.Because of the existing of heterogeneity across studies, randomized-effects models were used to calculate the pooled odds ratio.Subgroup analysis and meta-regression of age, gender and body mass index (BMI) were used to find their impact on the estimated effect.Sensitivity and publication bias analyses were also conducted to evaluate the reliability of the results.Results: Ten cross-sectional studies (3,031 participants) were included.Pooled odds ratio (OR) of OSA for the presence of MetS was 2.33(95% Cl: 1.85-2.93).The magnitude and direction of the effect was unaffected by age, gender and BMI and remained stable in the sensitivity analysis.There was publication bias but after the trim and fill analysis, the OR remained positive.Conclusion: In conclusion, OSA is associated with an increased risk of MetS prevalence independent of age, gender and BMI.OSA and MetS patients should be screened for the presence of each other in clinical practices.