【摘 要】
：
Alpha-Gal epitopes were synthesized on hepatocellular adenocarcinoma cell surface using neuraminidase and recombinant bovine α-1,3-galactosyltransferase (α-1,3-GT).The processed tumuor cells in the pr
【机 构】
：
Aerospace Medical College Peking University The Armed Police General Hospital China
论文部分内容阅读
Alpha-Gal epitopes were synthesized on hepatocellular adenocarcinoma cell surface using neuraminidase and recombinant bovine α-1,3-galactosyltransferase (α-1,3-GT).The processed tumuor cells in the presence of natural anti-Gal IgG antibody, resulted in the opsonization of effective phagocytosis by autogolous dendritic cells (DCs) which were cocultured with autologous CIKs to generate tumour specific immune responders ex vivo.The primary goal of this new technique, generation of α-Gal epitope capped tumour associated antigen (TAA) pulsed DCs and activation of tumour specific CIKs, was to assess the safety and bioactivity of this novel therapy.
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