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Polymeric micelle-based nano-carriers have exhibited a great potential in cancer therapy.Nevertheless,how to enhance the micellar stability and reduce the burst release is a key issue for improving the drug delivery efficiency in vivo.In order to enhance the stability of micellar nanovehicles,various strategies by reversibly cross-linking the core or shell of the micelles with stimulicleavable linkages have been developed [1,2].In our previous work,a disulfide cross-linked polyurethane micelle was developed.The doxorubicin (DOX)-loaded disulfide cross-linked micelles exhibited reduced cytotoxicity in vitro but displayed enhanced tumor suppression efficacy in vivo,likely due to the increased tumor accumulation of the drug-loaded cross-linked micelles [3].