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目的：评价利福喷丁对初治菌阳老年肺结核的疗效及肝功能的影响。方法：将143例60～79岁的初治菌阳肺结核患者随机分两组：利福喷丁治疗组（L组）57例；利福平治疗组（R组）86例，采用6个月疗程方案，即2HL1／EZ／4H2L1和HREZ／4H2R2，疗程结束评价疗效及副反应。随访2年。结果：L组和R组疫菌阴转率分别为94％和97．4％，两组比较无显著性差异。肺部X线改变显效率，空洞闭合率，空洞缩小率，组间比较P＞0．05。2年随访两组复发率分别为5．4％和2．7％，P＞0．05，但谷丙转氨酶升高，L组为3．5％，低于R组的14％；两组因肝损害而终止化疗分别为0例（0％）与7例（8．1％）有显著性差异。结论：利福喷丁与利福平均有效治疗菌阳老年肺结核。但前者较后者的肝损害少见。
Objective: To evaluate the effects of rifapentin on the efficacy and hepatic function of old-onset bacillary positive pulmonary tuberculosis. Methods: A total of 143 patients with newly diagnosed bacilli and pulmonary tuberculosis aged 60-79 years were randomly divided into two groups: 57 cases in the L group (L group) and 86 cases in the Rifampin group (R group) for 6 months Treatment regimens, namely, 2HL1 / EZ / 4H2L1 and HREZ / 4H2R2, the end of treatment evaluation of efficacy and side effects. Follow up for 2 years. Results: The negative rate of pathogenic bacteria in L and R groups was 94% and 97.4%, respectively. There was no significant difference between the two groups. P <0.05. The recurrence rates of the two groups were 5.4% and 2.7% respectively, P> 0.05, However, alanine aminotransferase was elevated in 3.5% of patients in group L, which was lower than 14% of patients in group R; 0% (0%) and 7 patients (8.1% Sex differences. Conclusion: Both rifapentine and rifampin are effective in treating elderly patients with pulmonary tuberculosis. However, the former liver damage than the latter rare.