自从发现乙型肝炎抗原(HBA_g)以来,无疑是提高了对乙型肝炎的诊断水平,但同时也进一步认识到了乙型肝炎确实是一个很复杂的问题。根据文献报道,在乙型肝炎表面抗原(HB_sA_g)阳性病人的各种组织及体液中,例如肝、肾、脑、心、肺、脾、肠系膜、卵巢以及唾液、胆液、精液、脑脊液和滑膜液中均已发现(HB_sA_g),这支持“乙型肝炎是一个全身性疾病”的概念。临床资料也已经证明,乙型肝炎病人,可以伴有肝外一个或二个甚至多个脏器受累的表现,例如可以伴有慢性腹泻、皮肤损害、多关节痛或多关 Since the discovery of hepatitis B antigen (HBA-g), it has undoubtedly raised the level of diagnosis of hepatitis B, but it is also further recognized that hepatitis B is indeed a very complicated issue. According to the literature, in various tissues and body fluids of patients with positive hepatitis B surface antigen (HB_sA_g) such as liver, kidney, brain, heart, lung, spleen, mesentery, ovary and saliva, bile, semen, Found in the membrane fluid (HB_sA_g), which supports the concept of “hepatitis B is a systemic disease.” Clinical data have also shown that patients with hepatitis B may be associated with manifestations of involvement of one or two or more organs outside the liver, for example with chronic diarrhea, skin damage, polyarticular pain or multiple