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目的探讨三维适形加量放射治疗在食管癌根治术后复发患者中的应用。方法42例纵隔转移肿瘤患者随机分为三维适形组和普放组,每组21例。结果两组完全缓解率分别为23.8 %,9.5 %;部分缓解率分别为71.4 %,81.0 %;总有效率(CR+PR)分别为95.2 %,90.5 %;两组比较无显著性(χ2 = 0.36,P>0.05)。两组(Ⅰ+Ⅱ)级急性放射性肺炎发生率分别为9.5 %,47.6 %,两组差异有显著性(χ2 = 7.47,P<0.01)。结论三维适形加量放射治疗在纵隔转移肿瘤中近期疗效好于普放治疗,远期疗效有待进一步观察。
Objective To investigate the application of three-dimensional conformal plus radiation therapy in patients with recurrent esophageal cancer after radical surgery. Methods Forty-two patients with mediastinal metastasis were randomly divided into 3-D conformal group and 21 cases in each group. Results The complete remission rate was 23.8% and 9.5% respectively. The partial remission rates were 71.4% and 81.0% respectively. The total effective rate (CR + PR) was 95.2% and 90.5% respectively. There was no significant difference between the two groups (χ2 = 0.36, P> 0.05). The incidence of acute radiation pneumonitis (Ⅰ + Ⅱ) in both groups was 9.5% and 47.6%, respectively. There was significant difference between the two groups (χ2 = 7.47, P <0.01). Conclusion Three-dimensional conformal plus radiation therapy in the mediastinal metastasis in the short term effect is better than the universal treatment, long-term efficacy remains to be further observed.