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许多微生物产生对免疫系统细胞有抑制和刺激作用的物质。这些产物也影响所致疾病的发病作用。不少微生物产生的毒素对多种T 细胞具有丝裂原作用。这些丝裂原性毒素的代表则是一些金黄色葡萄球菌株由噬菌体编码的毒素。葡萄球菌肠毒素(SE)在人类引起食物中毒,它们是一组结构上相关的蛋白质,分子量约26～30KD,有5种不同的血清型(A、B、C、D、E)。SE 的一个重要特点是对一些物种的T 细胞有极强的丝裂原性,低予10~(-8)浓度就足以刺激T 细胞,推想每个T 细胞只需很少几个SE 分子。目前,在效力上能与之相比的丝裂原只有抗
Many microorganisms produce substances that inhibit and stimulate immune system cells. These products also affect the pathogenesis of the disease caused. Many toxins produced by microorganisms have mitogenic effects on a variety of T cells. The representatives of these mitogenogenic toxins are some toxin encoded by phage from Staphylococcus aureus strains. Staphylococcal enterotoxins (SE) cause food poisoning in humans. They are a group of structurally related proteins with molecular weights of about 26-30 KD and five different serotypes (A, B, C, D, E). An important feature of SE is its strong mitogenicity for T cells of some species. A low concentration of 10-8 is enough to stimulate T cells. Suppose that only a few SE molecules are required per T cell. Currently, there is only resistance to mitogen in potency