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目的探讨早孕晚期采用药物流产的有效方法,以扩大药物流产的应用范围。方法选择2004年1月至2007年12月在本院确诊孕8-12周,自愿要求行药物流产的孕妇320例,按随机分为观察A组、观察B组、观察C组及对照组,各组均于第一、第二天口服米非司酮50mg,Q12h,总量共200mg,第三天早上阴道内放置前列醇片400ug(研碎),其中观察A组于服用米非司酮当天开始加服桂枝茯苓胶囊0.93g,Tid.;观察B组于服用米非司酮当天服用宫血宁胶囊0.26g,Tid;观察C组第一、二天服药方法同观察A组,第三天早上阴道内放置前列醇片同时加服宫血宁胶囊0.26g,Tid,各组加服药物均至排胎后1周;对照组按常规使用米非司酮加前列醇片,服药期间不加任何其他药物。观察各组孕囊排出时间、完全流产率、阴道出血情况及药物副反应情况。结果胎囊排出时间分别为观察A组(4.25±2.66)h、观察B组(4.89±3.88)h、观察C组(4.20±2.14)h、对照组(6.71±3.84)h、平均阴道流血量分别为(121.77±52.93)ml、(104.54±58.72)ml、(90.39±41.27)ml、(143.48±53.29)ml、平均出血时间分别为(13.10±3.73)d、(12.39±3.28)d、(7.87±3.42)d、(15.02±3.47)d、完全流产率分别为95.00%、91.25%、98.75%、78.75.%。观察组胎囊排出时间、平均出血时间明显短于对照组,平均阴道流血量少于对照组;完全流产率高于对照组,差异有显著性(P<0.01);观察C组与观察A组、观察B组比较,平均阴道流血量少,出血时间短,完全流产率高,差异有显著性(P<0.05)。结论桂枝茯苓胶囊配伍宫血宁胶囊辅助药物流产,可提高完全流产率,缩短胎囊排出时间,减少阴道流血量。
Objective To explore the effective methods of using medical abortion in the first trimester of pregnancy so as to expand the application range of medical abortion. Methods A total of 320 pregnant women were randomly selected from January 2004 to December 2007 at our hospital for 8-12 weeks and were randomly assigned to observation group A, observation group B, observation group C and control group. Each group were on the first and second days of oral mifepristone 50mg, Q12h, a total of 200mg, the third day of the morning vaginal plaque placed 400ug (grinding), which observed A group of taking mifepristone The same day began to add Guizhi Fuling capsule 0.93g, Tid .; observation group B taking mifepristone on the day of taking Gongxuening 0.26g, Tid; observation C group the first two days medication method with the observation group A, the third Day morning vaginal placing prothromycin tablets while serving Gongnongning Capsule 0.26g, Tid, each group plus medication to row after 1 week; control group according to conventional use of mifepristone plus prothrombin, medication during the period Add any other drugs. Observe the gestational sac of each group discharge time, complete abortion rate, vaginal bleeding and drug side effects. Results Fetal balloon discharge time were observed in group A (4.25 ± 2.66) h, group B (4.89 ± 3.88) h, group C (4.20 ± 2.14) h, control group (6.71 ± 3.84) h, mean vaginal bleeding The average bleeding time was (121.77 ± 52.93) ml, (104.54 ± 58.72) ml, (90.39 ± 41.27) ml and (143.48 ± 53.29) ml respectively. The mean bleeding times were (13.10 ± 3.73) d and (12.39 ± 3.28) 7.87 ± 3.42) d, (15.02 ± 3.47) d respectively. The rates of complete abortion were 95.00%, 91.25%, 98.75% and 78.75%, respectively. The mean time to bleeding in the observation group was significantly shorter than that in the control group, and the average vaginal bleeding time was less than that in the control group. The rate of complete abortion was higher than that in the control group (P <0.01) The observation group B, the average vaginal bleeding, bleeding time is short, the rate of complete abortion is high, the difference was significant (P <0.05). Conclusion Guizhi Fuling Capsule with Gongxuening Capsule assisted drug abortion, can improve the rate of complete abortion, shorten the time to discharge the sac and reduce vaginal bleeding.