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1956年Kisch首先发现豚鼠的心房肌细胞内含有一种颗粒。1964年Jamieson和Palade在哺乳动物的心房肌细胞中进一步观察到这种特殊颗粒,其形状及组织化学类似多肽激素颗粒,主要分布在心房肌细胞核的一侧或两侧,亦可散在分布于高尔基体之间。1976年,Marie等首先注意到这种颗粒随体内水、钠平衡变化而变化。直到70年代末、80年代初。DeBold等发现大鼠心房组织提取物给正常大鼠注射时,可以引起快速而强烈的利钠利尿作用。这样把Kisch发现的心房
In 1956 Kisch first found that guinea pig atrial myocytes contain a particle. Jamieson and Palade in 1964 further observed in mammalian atrial myocytes this special particles, the shape and histochemistry similar to peptide hormone particles, mainly located in the atrial muscle cell nucleus on one or both sides, but also scattered in the distribution of Golgi Between the body. In 1976, Marie et al. First noticed that the particles changed with the change of water and sodium balance in the body. Until the late 70s, early 80s. When DeBold et al found that the rat atrial tissue extract injected into normal rats, it can cause rapid and strong natriuretic effect. This puts Kisch in the atrium