目的　为了解豚鼠耳蜗Corti器组织中心钠素免疫反应 (Atrialnatriureticpeptidesimmunoreaction ,ANP -IR)物质的分布及形态学特征。方法　对耳蜗切片组织采用免疫组织化学ABC法进行研究。结果　Corti器中内侧第一、二排外毛细胞、Boettcher细胞和靠近螺旋韧带嵴的基底膜ANP -IR为阴性 ,其余的组织细胞均为阳性反应。结论　ANP在Corti器功能方面可能担负着重要的作用 ,三排外毛细胞中ANP -IR含量不同 ,其在功能上是否存在有差异 ,尚需进一步的研究 Objective To investigate the distribution and morphological features of Atrial natriuretic peptide drug (ANP-IR) in Corti tissue of guinea pigs. Methods Cochlear sections were studied by immunohistochemical ABC method. Results The first and second row of outer hair cells, Boettcher cells and the ANP-IR of the basement membrane near the spiral ligament ridge in the Corti were negative, and the rest of the cells were positive. Conclusions ANP may play an important role in the function of Corti. There are differences in the function of ANP-IR in three rows of outer hair cells, and further study is needed