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59例肝腹部囊性包虫病患者口服丙硫咪唑20mg/hg/d,共计3个疗程(90d)。(1)对用药后手术组21例与单纯手术组80例作对比研究,比较包虫内囊破裂率、囊壁病理损伤、原头蚴伊红着色率和对小鼠的感染率,结果有显著性差别(p 0.01)。(2)对38例用药非手术组的治疗和随访,结果治愈8例(21.1％),改善21例(55.3％),无效9例(23.7％)。(3)对12例肝包虫患者应用高效液相色谱法进行药物监测,丙硫咪唑亚砜在包虫囊液中浓度为411±130μg/L,分别为血液和胆汁中浓度的1/2.5和1/5。
Fifty-nine patients with cystic echinococcosis were given oral albendazole 20mg / hg / d for 3 courses (90 days). (1) Comparison of 21 cases of operation group and 80 cases of simple operation group after drug treatment, compared the rupture rate of hydatid cyst, the pathological damage of cystic wall, the eosin staining of eucalyptus and the infection rate to mice Significant difference (p <0.01). (2) 38 cases of non-surgical treatment and follow-up, the results were cured in 8 cases (21.1%), improved in 21 cases (55.3%), ineffective in 9 cases (23.7%). (3) Drugs monitoring was performed in 12 patients with hepatic hydatid disease by HPLC. The concentration of albendazole sulfoxide in hydatid cyst was 411 ± 130μg / L, which was 1 / 2.5 of the concentration in blood and bile, respectively And 1/5.