慢性化脓性中耳炎在成年人的发病率为0.6％,常由细菌经穿孔的鼓膜或经咽鼓管侵入以致形成急性发作,药物治疗包括耳部清洗和局部用药。将鼓膜中央性穿孔患者随机抽样分成两组,第一组29例应用0.3％氧氟沙星滴耳液滴耳,每日3次连续7天,第二组27例口服羟氨苄青霉素-克拉维酸375mg,每日3次连服7天。治疗结果氧氟沙星组29例中22例(76％)完全干耳,无1例有不良副反应或过敏,纯音骨导测试0.5,1, Chronic suppurative otitis media in adults, the incidence of 0.6%, often by bacterial perforation of the tympanic membrane or eustachian tube invasion caused by the formation of an acute attack, drug treatment, including ear cleaning and topical application. The patients with central perforation of the tympanic membrane were randomly divided into two groups. In the first group, 29 cases received 0.3% of ofloxacin ear drops ear drops 3 times a day for 7 consecutive days, the second group of 27 cases of oral amoxicillin - Acid 375mg, 3 times a day for 7 days. Treatment outcome Ofloxacin group of 29 cases, 22 cases (76%) completely dry ears, no one had adverse side effects or allergies, pure tone bone conduction test 0.5,1,