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本研究采用栓塞大脑中动脉的方法建立了大鼠可恢复血流的局部脑缺血模型,观察了永久栓塞和栓塞3小时后复流2组大鼠的神经症状、脑肿胀程度和脑梗塞范围,结果显示两组间未达统计学差异.但病理检查发现3只大鼠复流后梗塞灶局限于基底节及复流后的脑梗塞区内有血管周围灶性出血现象.作者就动物模型和上述现象及其临床意义进行了讨论.
In this study, we established a rat model of cerebral ischemia with recoverable blood flow by embolization of the middle cerebral artery and observed the neurological symptoms, brain swelling and extent of cerebral infarction , The results showed that no statistical difference between the two groups.But the pathological examination found that 3 rats after infarction infarction is limited to the basal ganglia and cerebral infarction after reflow within the perivascular foci of hemorrhage.About the animal model And the above phenomenon and its clinical significance are discussed.