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背景:庚型肝炎病毒(HGV)是一种血生黄病毒,能引起急性和慢性输血传播感染。患有补体成分I(CI)抑制剂(CI-INH)缺乏症的病人,可能通过血浆浓制剂的输注患血生病毒传染病。研究方案和方法:血清样本取自84例前述病人(19例注射了未经修饰的CI-INH浓制剂。23例注射了蒸气热处理的浓制剂,42例未经治疗)。采用巢式PCR测定HGV RNA和HCV RNA。测定HGV的E2包膜蛋白抗体(抗-HGV)和用酶联免疫吸附试验测抗HCV。结果:9例(11％)病人检出血液HGV RNA,其中7
Background: Hepatitis G virus (HGV) is a blood-borne flavivirus that causes both acute and chronic transfusion-transmitted infections. Patients with a deficiency of complement component I (CI) inhibitor (CI-INH) may develop a blood-borne viral infection through the infusion of plasma concentrates. PROCEDURES AND METHODS: Serum samples were obtained from 84 patients (19 with unmodified CI-INH concentrate, 23 with steam heat-treated concentrates and 42 with no treatment). HGV RNA and HCV RNA were determined by nested PCR. The HGV E2 envelope protein antibody (anti-HGV) was assayed and tested for anti-HCV by enzyme-linked immunosorbent assay. Results: Blood HGV RNA was detected in 9 (11%) patients, 7 of them