证明黑素细胞抗体很困难,它需要用灵敏的免疫荧光补体结合试验(ICFT)。从Hertz等1977年首先报告以来,包括本文2例全世界共搜集到9例有黑素细胞抗体。其中特发性甲状旁腺功能不全并发念珠菌病和白癜风6例;甲状旁腺功能不全、溃疡性结肠炎和念珠菌病1例;仅有念珠菌病者2例。作者使用ICFT于黑素细胞的经验是:诊断为自身免疫多内分泌腺综合征Ⅰ型并发白癜风和慢性念珠菌病者7例,抗黑素细胞抗体阳性4例;另外自身免疫多内分泌腺综合征Ⅰ型并发白癜风患者7例,自身免疫多内分泌腺综合征Ⅱ型合并白癜风患 Proven melanocyte antibodies are difficult and require sensitive immunofluorescence complement fixation assays (ICFTs). From the first report of Hertz et al. In 1977, 9 cases of melanocyte antibodies were collected in 2 cases worldwide. Including idiopathic parathyroid dysfunction and candidiasis and vitiligo in 6 cases; parathyroid dysfunction, ulcerative colitis and candidiasis in 1 case; only candidiasis in 2 cases. The authors’ experiences with ICFT in melanocytes were: 7 cases diagnosed as autoimmune polyendocrine syndrome type I with vitiligo and chronic candidiasis, 4 cases with anti-melanocyte antibody positive; additionally, autoimmune polyendocrine syndrome Ⅰ type of patients with vitiligo in 7 cases, autoimmune polyendocrine syndrome type Ⅱ with vitiligo