COPD激素治疗的逻辑 根据病理生理基础和支气管哮喘对激素的良好反应,人们认为,吸入激素治疗可阻止肺功能的进一步恶化,且在提高生活质量的同时降低了恶化率和死亡率,因而数年来国际国内推荐COPD的激素治疗。但该推荐仅以稳定期为基础,从时间和病例数上都显证据不足。经过10年研究,认识到激素治疗的有效性不能由支气管哮喘推广到COPD。国际建议中一再指出,要迅速减量,避免全身长期激素治疗和经验主义的治疗。 The Logic of COPD Hormone Therapy Based on the pathophysiological basis and the good response of hormones to bronchial asthma, inhaled hormone therapy is thought to prevent further deterioration of lung function and reduce the deterioration rate and mortality while improving the quality of life International and domestic recommended hormone therapy of COPD. However, the recommendation is based on stable periods only, with insufficient evidence from time and number of cases. After 10 years of research, I realized that the effectiveness of hormonal therapy can not be extended to COPD by bronchial asthma. International recommendations have repeatedly pointed out that the rapid reduction should be avoided to avoid long-term systemic hormone therapy and empiricism.