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酮基氯苯咪唑(Ketoconazole)在试管中对很多霉菌具有拮抗作用,口服吸收良好,长期服用毒性轻微。本文作者报告了11例12次霉菌性尿路感染采用本药的疗效。材料和方法:凡成人病例>1次的肾盂(肾造口管)或膀胱中段尿培养酵母菌阳性者则接受治疗,大多数病例其菌落计数>10~5/ml。10例酮基氯苯咪唑开始剂量200mg/日,若数日内仍有霉菌则剂量增至400mg/日。肾盂尿培养阳性者为上尿路感染,其它为下尿路感染,治疗后尿培养阴性为有效。疗程中大多数病例作了反复尿培养,治疗后随访≧1周。病例1,7和8采用Levine和Cobb法作了最低抑菌浓度测定,其他病例用酪蛋白酵母葡萄糖浸膏琼脂作了酮基氯苯咪唑琼脂稀释敏感试验测定。采用Jorgensen等的方法作了尿浓度测定。结果:凡酮基氯苯咪唑剂量愈大则尿浓度愈高,凡剂量400mg/日者≦4小时的尿浓度为0.25至1.12
Ketoconazole has an antagonistic effect on many molds in test tubes, is well absorbed orally, and is less toxic in long-term use. The authors reported 11 cases of 12 mycotic urinary tract infections with the efficacy of the drug. MATERIALS AND METHODS: All cases of renal pelvis (nephrostomy tube) or urinary culture of yeast positive in the middle of the urinary tract were treated for> 1 time. In most cases, their colonies count> 10 ~ 5 / ml. 10 cases of ketoprofen imidazole start dose 200mg / day, if the number of days there are still mold increased to 400mg / day. Urine culture positive for urinary tract infection, the other for the lower urinary tract infection, urine culture negative after treatment is effective. Most of the cases during the course of treatment were repeated urine culture, follow-up after treatment ≧ 1 week. Cases 1, 7 and 8 were tested for the minimum inhibitory concentrations using the Levine and Cobb methods. Other cases were assayed for susceptibility to ketorbaxin agar dilution using casein yeast glucose agar. The urine concentration was determined by the method of Jorgensen et al. Results: The greater the ketanamizole dose, the higher the urinary concentration, where the concentration of urine at a dose of 400 mg / day ≦ 4 hours was 0.25 to 1.12