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目的:探析不同剂量枸缘酸咖啡因治疗早产儿呼吸暂停(AOP)的临床效果。方法:选择肇庆市端州区妇幼保健院2015年1月至2017年1月新生儿重症监护病房(NICU)收治的90例呼吸暂停早产儿为研究对象,根据数字随机法将其分为两组,其中给予对照组枸缘酸钠咖啡因5 mg·kg~(-1)维持剂量,而观察组则运用枸缘酸钠咖啡因15 mg·kg~(-1)维持剂量,对两组的治疗效果进行比较分析。结果:与对照组相比,观察组的不良反应发生率低,但是组间比较,差异均无统计学意义(P>0.05);相比较对照组而言,观察组使用呼吸机时间和症状消失时间均较短,差异具有统计学意义(P<0.05);同时,用药第1天、第2天以及第3天两组的呼吸暂停发生次数和严重程度比较,差异具有统计学意义(P<0.05)。结论:临床上给予呼吸暂停早产儿枸缘酸钠咖啡因15 mg·kg~(-1)维持剂量治疗,能够改善症状,降低不良反应发生率。
Objective: To investigate the clinical effects of different doses of caffeic acid caffeine on apnea (AOP) in preterm infants. Methods: Ninety premature infants with apnea who were admitted to Neonatal Intensive Care Unit (NICU) from January 2015 to January 2017 in Duanzhou District Maternal and Child Health Hospital of Zhaoqing City were selected as study subjects and divided into two groups according to the digital random method , In which the control group was given sodium citrate caffeine 5 mg · kg -1 (maintenance dose), while the observation group was the use of sodium citrate caffeine 15 mg · kg -1 (-1) maintenance dose, the two groups Therapeutic effects were compared. Results: Compared with the control group, the incidence of adverse reactions in the observation group was low, but there was no significant difference between the two groups (P> 0.05). Compared with the control group, the use of ventilator time and symptoms disappeared in the observation group (P <0.05). At the same time, there were significant differences in the number and severity of apnea between the two groups on the first day, the second day and the third day after treatment (P < 0.05). Conclusion: Clopidogrel sodium caffeine 15 mg · kg ~ (-1) is the best choice in the treatment of premature infants with apnea. It can improve the symptoms and reduce the incidence of adverse reactions.