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通过一例经手术，病理证实的Merkel细胞瘤，复习了相关文献，对该病的临床特征，诊断，治疗原则，预后因素及分子生物学研究进展进行了讨论。Merkel细胞瘤是起源于浅表皮肤Merkel细胞的恶性肿瘤，属于神经内分泌瘤。肿瘤常见于头颈部及四肢，易局部复发并转移。主要靠病理诊断，易与淋巴瘤混淆。发病早期即主张行胸腹部CT检查以确定分期。治疗原则倾向于先作肿物广泛切除，淋巴结清扫，尔后放疗。化疗的作用尚不能肯定。局部复发及有远处转移者预后差。本病发生与BC1-2基因及FHIT基因有关，与P53基因无关。
The clinical features, diagnosis, treatment principles, prognostic factors and progress of molecular biology were reviewed through a review of the relevant literature by a surgically and pathologically confirmed Merkel cell tumor. Merkel’s tumor is a malignant tumor of Merkel cells that originates from superficial skin and belongs to neuroendocrine tumors. Tumors are common in the head and neck and limbs, and local recurrence and metastasis. Mainly by pathological diagnosis, easy to confuse with lymphoma. The incidence of early advocate of chest and abdomen CT examination to determine the staging. The treatment principle tends to make extensive removal of the tumor first, lymph node dissection, followed by radiotherapy. The role of chemotherapy is still not sure. Local recurrence and distant metastasis are poor prognosis. The disease occurs with the BC1-2 gene and FHIT gene, has nothing to do with the P53 gene.