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目的 探讨SARS密切接触者中是否有隐性感染者及评估防制措施的落实情况。方法 对广元市 88名SARS患者密切接触者进行随访 ,用“SARS病例密切接触者调查问卷”调查密切接触者的人口学特征、接触情况、防护情况及身体状况 ,用酶联免疫双抗原夹心法检测血清中特异性SARS冠状病毒总抗体水平。结果 4名医务工作者检出SARS病毒总抗体阳性 ,阳性率 4 5 % ;密切接触者的个人综合防护率为 14 8% ;医务防疫人员在国家将SARS纳入法定传染病管理前后 ,个人综合防护率有显著提高 (R控制前 =9 5 % ;R控制后 =2 9 1% ,P <0 0 5 )。结论 SABS密切接触者中存在隐性感染者 ;及早采取综合防制措施可有效控制SARS的流行 ;加强高危人群个人防护和控制医院内感染是防制工作的重点
Objective To investigate the presence of latent infection in close contacts of SARS and evaluate the implementation of control measures. Methods The close contacts of 88 SARS patients in Guangyuan City were followed up. The demographic characteristics, exposure, protection status and physical status of close contacts were investigated with the questionnaire of close contacts of SARS cases. Serum total SARS-CoV antibody levels were measured. Results Four medical workers were positive for total SARS antibody, with a positive rate of 45%. The personal comprehensive protection rate of close contacts was 14.8%. Before and after the national epidemic prevention agency incorporated SARS into the administration of the legal infectious disease, the personal comprehensive protection rate There was a significant improvement (R = 95% before R control = 291% after R control, P <0 05). Conclusions There are latent infections in the close contacts of SABS. Early comprehensive prevention and control measures can effectively control the epidemic of SARS. Strengthening personal protection of high-risk groups and controlling in-hospital infections are the focus of prevention and control