论文部分内容阅读
目的探讨氟加钙联合疗法对实验大鼠骨质疏松疗效,找出一种治疗老年性骨质疏松的规范方法。方法采用3月龄雌性大鼠去卵巢,建立女性增龄型骨质疏松模型,并分别单纯给氟或钙,联合应用氟加钙口服,6个月后取大鼠左侧胫骨近端进行松质骨形态计量学分析,对比3种方法对该骨质疏松模型的治疗作用。结果大鼠去卵巢6个月后可出现松质骨骨量丢失(P<0.05),微细结构破坏(P<0.05),骨转换加快(P<0.05),模型建立成功。单纯应用小剂量氟和单纯补钙对改善模型的骨量、微结构及骨转换方面有一定作用,但不如联合应用氟加钙作用明显。高剂量氟加钙的方法、疗效更加显著。结论氟加钙疗法比单纯应用氟或钙疗效更好。
Objective To investigate the effect of fluoride plus calcium combination therapy on experimental osteoporosis in rats and to find out a standardized method for the treatment of senile osteoporosis. Methods 3-month-old female rats were ovariectomized to establish the model of female osteoporosis. The rats were treated with fluoride or calcium alone, combined with fluoride and calcium. Six months later, the proximal tibia of rats Histomorphometric analysis was used to compare the therapeutic effects of the three methods on this osteoporosis model. Results After ovariectomized for 6 months, the amount of cancellous bone loss (P <0.05), the destruction of fine structure (P <0.05), the accelerated bone turnover (P <0.05) and the successful establishment of the model. Simple application of small doses of fluoride and calcium alone to improve the model of bone mass, microstructure and bone turnover have a certain role, but not as good as the combination of fluoride and calcium significantly. High-dose fluoride plus calcium method, the effect is more significant. Conclusion Fluoride plus calcium therapy is better than fluoride or calcium alone.