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本文检测寻常型银屑病13例,高血压病5例,正常人7例血浆血栓烷B_2(TXB_2)和6-酮-前列腺素F_(1α)(6-酮-PGF_(1α))含量。银屑病患者TXB_2为正常人3倍,6-酮-PGF_(1α)比正常稍高。TXB_2和6-酮-PGF_(1α)均增高,提示花生四烯酸(AA)在本病中增高。AA增高可激活鸟苷酸环化酶、抑制腺苷酸环化酶,使cGMP增多,cAMP减少而引起表皮细胞增殖。TXB_2/6-酮-PGF_(1α)比正常稍高可说明本病血粘度增高及血小板聚集性增高的发生机理。高血压病6-酮-PGF_(1α)也比正常高2.6倍,伴有心衰和高心的2例TXB_2明显低于正常,因病例数较少尚待进一步探研。
In this study, 13 cases of psoriasis vulgaris, 5 cases of hypertension and 7 cases of normal control group were measured TXB_2 and 6-keto-PGF 1α. Psoriasis patients TXB_2 3 times normal, 6-keto-PGF_ (1α) slightly higher than normal. TXB_2 and 6-keto-PGF_ (1α) were increased, suggesting that arachidonic acid (AA) increased in this disease. Increased AA can activate guanylate cyclase, inhibition of adenylate cyclase, cGMP increased cAMP decreased caused by epidermal cell proliferation. TXB_2 / 6-keto-PGF_ (1α) slightly higher than normal may explain the pathogenesis of increased blood viscosity and increased platelet aggregation. Hypertension 6-keto-PGF_ (1α) was also 2.6-fold higher than normal, accompanied by heart failure and high heart 2 TXB_2 was significantly lower than normal, due to the smaller number of cases to be further exploration.