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近年来随着新生儿重症医学的发展,早产儿尤其是极低出生体质量儿的存活率得到提高[1],早产儿各种并发症也逐渐受到关注,如早产儿代谢性骨病(metabolic bone disease of prematurity,MBDP)。MBDP是由早产儿体内矿物质含量异常所导致的骨小梁数量减少、骨皮质变薄等骨骼改变的疾病[2],短期内可引起自发性骨折及呼吸系统疾病[3-4],且与早产儿近视有一定关系[3,5-6],长期影响则与儿童及成年期身材矮小有关[2-6]。国内外尚无统一的诊断标准,临床诊断时多已有明显
In recent years, with the development of newborn’s critical medicine, the survival rate of preterm infants, especially those with very low birth weight, has been raised [1]. Various complications of premature infants are also gradually receiving attention. For example, metabolic bone disease bone disease of prematurity, MBDP). MBDP is a disorder of skeletal changes caused by the decrease of trabecular number and thinning of cortical bone caused by abnormal mineral content in preterm infants [2], which may cause spontaneous fractures and respiratory diseases in the short term [3-4] Myopia and preterm children have a certain relationship [3,5-6], long-term effects and short stature in children and adulthood [2-6]. There is no uniform diagnostic criteria at home and abroad, clinical diagnosis has been more obvious