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目的比较薤白联合阿司匹林或单用阿司匹林防治心脑血管事件的疗效。方法 2007年1月2009年9月就诊的188例高危患者纳入研究,随机分为实验组(89例)和对照组(99例)。两组均予口服阿司匹林0.1g,1次/d。实验组同时给予口服薤白0.9g,3次/d。观察两组患者血管事件的发生率和不良反应的发生情况。结果实验组血管总事件发生率为6.7%,对照组为19.2%,两组间差异有统计学意义(P<0.05);实验组脑梗死发生率为1.1%,对照组为9.1%,两组间差异有统计学意义(P<0.05)。两组短暂性脑缺血、心绞痛、心肌梗死的发生率比较,差异无统计学意义(P>0.05)。两组皮下出血、血尿、黑便、恶心、腹痛等不良反应的发生率比较,差异无统计学意义(P>0.05)。结论服用阿司匹林加薤白可显著降低高危患者心脑血管总事件发生率和脑梗死发生率,增加疗效,而不良反应没有显著增加。
Objective To compare the curative effect of 薤 Bai combined with aspirin or aspirin alone in the prevention and treatment of cardiovascular and cerebrovascular events. Methods A total of 188 high-risk patients treated in January 2007 and September 2009 were included in the study and were randomly divided into experimental group (n = 89) and control group (n = 99). Two groups were given aspirin 0.1g, 1 time / d. The experimental group was given orally Bai Ling 0.9g, 3 times / d. The incidence of vascular events and the incidence of adverse reactions in both groups were observed. Results The incidence of vascular events was 6.7% in the experimental group and 19.2% in the control group, with a significant difference between the two groups (P <0.05). The incidence of cerebral infarction in the experimental group was 1.1% and that in the control group was 9.1% The difference was statistically significant (P <0.05). The incidence of transient ischemic attack, angina pectoris and myocardial infarction in the two groups had no significant difference (P> 0.05). There was no significant difference in the incidence of adverse reactions such as subcutaneous hemorrhage, hematuria, melena, nausea and abdominal pain between the two groups (P> 0.05). Conclusion Aspirin plus 薤 Bai can significantly reduce the incidence of cardiovascular and cerebrovascular events in high-risk patients and the incidence of cerebral infarction, increase the efficacy, and no significant increase in adverse reactions.