用Dot-ELISA观察人工感染2株不同剂量的弓形虫家兔血清循环抗原(CAg)动态。结果感染RH株弓形虫速殖子10~4/只和10~2/只的两组家兔,CAg出现和全部阳转时间均在感染后3d。但RH株的感染量影响宿主血清CAg动态。感染PP株10~6/只和10~4/只的两组家兔,血清CAg变化无明显差异。RH株CAg水平变化急骤,而PP株变化较平缓,表明宿主血清CAg动态与弓形虫虫株毒力密切相关。 Dot-ELISA was used to observe the dynamic changes of CAg in two different doses of Toxoplasma gondii rabbit. Results Two rabbits infected with Toxoplasma gondii tachyzoites at 10-4 / only and 10-2 / t had CAg appearances and all of the positive rotation time were all 3d after infection. However, the infection of RH strain affected the dynamics of host serum CAg. There was no significant difference in serum CAg between two groups of rabbits infected with PP strains 10 ~ 6 / only and 10 ~ 4 / only. RH strain CAg level changes rapidly, while the PP strain changes more moderate, indicating that the host serum CAg dynamics and Toxoplasma gondii strain virulence are closely related.