目的　探讨抗癫药物高度敏感综合征 (AHS)的临床特点及治疗方法。方法　对收治的AHS 9例临床资料回顾分析。结果　 9例均有发热、皮疹。多形性红斑、重型多形性红斑各 2例 ,中毒性表皮松解征 3例 ,剥脱性皮炎、猩红热样皮疹各 1例。肝功能异常 6例 ,肺炎、血尿和 (或 )蛋白尿各 3例。给甲基强的松龙治疗 ,除 1例死亡外 ,余均痊愈出院。结论　在综合治疗基础上 ,及时应用甲基强的松龙治疗AHS ,疗效可靠 ,未见明显副作用 Objective To investigate the clinical features and treatment of anti-epileptic drug highly sensitive syndrome (AHS). Methods A retrospective analysis of clinical data of 9 cases of AHS admitted. Results 9 cases had fever and rash. Erythema multiforme, severe erythema multiforme in 2 cases, 3 cases of toxic epidermolysis syndrome, exfoliative dermatitis, 1 case of scarlet fever-like rash. 6 cases of abnormal liver function, 3 cases of pneumonia, hematuria and / or proteinuria. Methylprednisolone treatment, except one case of death, the remaining were cured. Conclusion On the basis of comprehensive treatment, prompt treatment of AHS with methylprednisolone is reliable and has no obvious side effects