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目的探讨α-干扰素栓联合LEEP刀治疗人乳头瘤病毒感染宫颈糜烂临床效果。方法抽取2014年4月—2015年6月北海市第二人民医院收治的符合选取标准的64例人乳头瘤病毒感染宫颈糜烂患者,根据治疗方案不同分为研究组(n=32)与对照组(n=32)。对照组仅采用LEEP刀实施手术治疗,研究组采用α-干扰素栓联合LEEP刀治疗。比较两组临床疗效、创面愈合时间、1年后疾病复发情况及不良反应发生情况。结果研究组总有效率为93.75%,对照组为68.75%,差异有统计学意义(P<0.05);研究组1年后疾病复发率为9.38%,对照组复发率为34.38%,差异有统计学意义(P<0.05);研究组和对照组创面愈合时间分别为(5.40±2.22)、(9.56±2.37)d,差异有统计学意义(P<0.05);研究组治疗后不良反应发生率为12.51%,对照组为40.64%,差异有统计学意义(P<0.05)。结论α-干扰素栓联合LEEP刀治疗人乳头瘤病毒感染宫颈糜烂疗效确切,可有效改善患者临床症状,促进创面愈合,改善临床疗效及预后,且不良反应发生率较低,具有安全性。
Objective To investigate the clinical effect of α-interferon suppository combined with LEEP knife in treating cervical erosion of human papillomavirus (HPV) infection. Methods A total of 64 patients with cervical erosion who met the selection criteria from April 2014 to June 2015 in Beihai Second People’s Hospital were divided into study group (n = 32) and control group according to different treatment plans (n = 32). The control group was treated with LEEP knife only. The study group was treated with α-interferon suppository and LEEP knife. The clinical efficacy, wound healing time, disease recurrence after 1 year and the incidence of adverse reactions were compared between the two groups. Results The total effective rate was 93.75% in the study group and 68.75% in the control group, the difference was statistically significant (P <0.05). The recurrence rate of the study group after one year was 9.38% and that of the control group was 34.38% (P <0.05). The wound healing time of the study group and the control group were (5.40 ± 2.22) and (9.56 ± 2.37) days, respectively, with significant difference (P <0.05). The incidence of adverse reactions Was 12.51% in the control group and 40.64% in the control group, the difference was statistically significant (P <0.05). Conclusion The combination of α-interferon suppository and LEEP knife is effective in treating cervical erosion of human papillomavirus infection, which can effectively improve the clinical symptoms, promote wound healing, improve clinical curative effect and prognosis, and the incidence of adverse reactions is low and safe.